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Similarly, the quinolinium containing parent analogue 1-MQ also lacked passive diffusion properties (Table 1), suggesting that the lipophilicity and drug-like permeability properties of analogues within the methylquinolinium series had to be improved via chemical modification

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Deth, and H

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This cysteine-homocysteinylation event perturbs the pro-insulin receptor and furin protease interaction within the Golgi apparatus, consequently inhibiting the cleavage of the pro-insulin receptor

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