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Results Single-cell and spatial analyses identify collagen-mediated immunosuppression as a predominant feature of the meningioma microenvironment To characterize the immunobiology of meningiomas and to identify immune therapeutic targets, single-cell RNA-seq (scRNA-seq) datasets with adjacent dura samples 2,3 were analyzed

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Combination strategies further expand therapeutic potential: PERK inhibitors paired with mRNA vaccines remodel the immune microenvironment in glioblastoma [24]

274 This adaptive mechanism allows certain CSCs to withstand metabolic stress and avoid excessive ROS generation

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