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Measurements with NBD-Sph revealed a twofold stronger binding affinity at neutral compared with acidic pH (K D 120 nM compared with K D 250 nM, Fig 3F and G)

Using this paper-based device a LOD of 5.1 pmol, a limit of quantification (LOQ) of 16.9 pmol and a linear region of 5100 pmol were found [75]

To help prevent this severe adverse risk, sexually active women must use two forms of contraception, and pregnancy testing is required for all female patients of childbearing potential at baseline and monthly until completion of therapy

(PubMed) Jeppesen PB, Hoy CE, Mortensen PB

It is safe for long-term use when taken within recommended dosage guidelines

Archived from the original on December 31, 2022