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On one hand, SGECs release significant amounts of autoantigens (such as Ro/SSA and La/SSB) through apoptotic blebs and exosomes (22, 23)

6.1 The vascular endothelial dysfunction Endothelial cells line the inner layer of blood vessels and play critical roles in regulating vascular tone, maintaining blood flow, and providing anticoagulant properties

While the functional impact of all polymorphisms has not been characterized, some polymorphisms in DNA repair genes or their regulatory sequences do induce phenotypical changes and are involved in cancer development

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