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These lifestyle predispositions can create an environment that allows for certain root cause factors to develop, which begins the self-perpetuating cycle that is Hashimotos

Oxidative stress can impair the function of antiproteases, such as 1-antitrypsin and secretory leukoprotease inhibitor, thereby accelerating the breakdown of elastin in the lung parenchyma

Berthou C, Iliou JP, Barba D (2022) Iron, neuro-bioavailability and depression

The immune system appears to play a pivotal role in these conditions, with evidence of T-cell and B-cell dysfunction, including signs of exhaustion in ME/CFS

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Notably, several factors reported may limit the clinical impact of such agents [62]
