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Immune Function Regulation: Research suggests that L-Glutathione plays a vital role in regulating immune function by balancing oxidative stress and fine-tuning immune responses

J Clin Oncol 26 (24): 3971-8, 2008

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However, given the anionic nature of GSH at physiologic pH, it cannot diffuse across the mitochondrial inner membrane (MIM) into the matrix because of the oxidative phosphorylativemediated negative membrane potential relative to the cytoplasm