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Specifically, the indirect mechanism is chelation of transition metals, which prevents participation within the Haber-Weiss (Kehrer, 2000) or Fenton reaction, while the direct mechanism involves donating or receiving of electrons, scavenging radicals, and consequently preventing their reaction with biological molecules

In acute gouty arthritis, traditional Chinese medicine formulations have been used to suppress caspase-1 activation and IL-1 production, thereby inhibiting NLRP3 inflammasome activation and pyroptosis in THP-1 cells, ultimately improving disease outcomes (Wang N

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When combined, researchers examine how these two peptides may produce synergistic effects in preclinical models and cellular experiments