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Mice were first familiarized to the treadmill for three non-consecutive days for 5 min at a walking speed (8 m/min)

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Preclinical studies showed no adverse effects across several organ systems including liver, spleen, lung, kidney, brain, thymus, prostate, and ovaries in studies up to 6 weeks

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The primary outcome measure being assessed was the change in HbA1c from baseline to the end of treatment at week 32, while seconday outcome measures were related to endpoints of continuous glucose monitoring included time in range and time aboe range [2]

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