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Increased amounts of cytokines like IL-6 and TGF- block enzymes that are contributory to the synthesis of GSH, exacerbating the GSH depletion [36]

Unfortunately, its levels are often lower than they should be and the factors contributing to it are mostly poor diet and malnutrition, chronic stress, age, toxins, and overall inflammation

10.1124/jpet.105.094979 J

10.1016/S0964-8305(98)00036-5 239 stmanM.FickJ.TysklindM

Impact of NAD+ metabolism on ovarian aging