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The Baltimore Longitudinal Study of Aging, investigating a total number of 669 individuals with an average age of 67 years, showed that participants with lower mitochondrial oxidative capacity exhibited hallmarks of inflammation, specifically showing markedly higher levels of interleukin-6 and C-reactive protein, as well as increased erythrocyte sedimentation rate compared with participants with better oxidative capacity, independent of age and sex (Zampino et al., 2020)

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On the other hand, insulin supplementation did not affect starvation time ( 9.3.1 Function of the Gut Barrier SCFAs and butyrate are considered critical substances for the maintenance of a healthy gut

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10.1039/a805957h [DOI] [Google Scholar] Dennys CN, Roussel F, Rodrigo R, Zhang X, Sierra Delgado A, Hartlaub A, Saelim-Ector A, Ray W, Heintzman S, Fox A, Kolb SJ, Beckman J, Franco MC, & Meyer K (2023)