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Upon certain cellular stresses, p53 is activated and then increases the expression of PUMA, NOXA and BIM, which inhibit the pro-survival BCL-2 proteins, leading to the activation of the effectors of apoptosis, BAX and BAK

[DOI] [Google Scholar] 290.Orton R.J., Sturm O.E., Vyshemirsky V., Calder M., Gilbert D.R., Kolch W

Patients should be advised that neurological recovery may take several months and, in some cases, may be incomplete if treatment is delayed

Repeated injections in the same area will help prevent muscle fatigue or discomfort

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