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In response to ER stress, the UPR helps cells adapt to and survive the stress condition by transcriptional and translational reprogramming

Isolated cells were stained with the following: antibodies against mouse CD45 (30-F11

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Overexpression of TM6SF2 led to an increase in total cholesterol and LDL cholesterol (LDL-c), and a decrease in HDL-c, while downregulation of TM6SF2 may lead to a decrease in total cholesterol