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Among them, the N-alkyl-lenalidomide based PROTAC 83 stands out, inducing the UPS- and concentration-dependent degradation of BTK (DC 50 = 7.0 nM, D max = 96.5%) without inducing the degradation of cereblon neo-substrates IKZF1/3

Recently, glutamine metabolism has been shown to be linked to white adipose tissue (WAT) inflammation in obesity 110

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That leads to unrealistic expectations

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