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Lipid accumulation might play an indispensable part in the advancement of renal tubular fibrosis and glomerulosclerosis (173)

Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations

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Thromb Haemost 96:488491 Eldor A, Durst R, Hy-Am E, Goldfarb A, Gillis S, Rachmilewitz EA, Abramov A, Maclouf J, Godefray YC, de Raucourt E, Guillin MC (1999) A chronic hypercoagulable state in patients with beta-thalassaemia major is already present in childhood
An in vitro study showed that evolocumab could significantly reduce the concentration of malondialdehyde (MDA) and the ROS-mediated oxidative damage in human umbilical vein endothelial cells [45]
