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This finding is consistent with decades of periodontal research demonstrating that gingivitis is reversible with adequate plaque control, and it provides essential context for interpreting the additional effects of matcha tea consumption

The MTT assay (0.5, 2, 4, 8 g/ml NPs after 48 h) has shown comparable cytotoxic effects to sunitinib, which demonstrated the promising future of this drug delivery system (Otroj et al., 2020)

However, the most dominant component in it is hyaluronic acid

Receiver operating characteristic curve in diagnostic test assessment

Moving forward, emphasis should shift from reiterating preclinical challenges toward designing rigorous, biomarker-driven randomized controlled trials that can define their true clinical value

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