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Description
Carnitine deficiency has been reported in chronic illnesses such as cancer [91]

A case-control study of 427 pairs of individuals with and without incident diabetes nested in the Diabetes Prevention Program (DPP) found that low plasma betaine at baseline was associated with an increased risk of incident diabetes

For each clinical study that described a biomarker, a level of evidence (LOE) ranging from one to five was assigned

doi: 10.1152/physiolgenomics.00136.2014 139 AdnanSNelsonJWAjamiNJVennaVRPetrosinoJFBryanRMJr.et al

ACS Chem

doi: 10.1016/j.cmet.2015.08.024 76
