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10.2174/138527212799957995 32 DaviesS

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A critical underlying mechanism involves oxidative stress (OS), an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, which disrupts endothelial function, reduces nitric oxide (NO) bioavailability, and contributes to vascular dysfunction

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gingivalis , thus leading to growth inhibition and biofilm formation (Dashper et al., 2012)