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This observation may be attributed to the specific pathways these inhibitors target and the redundancy of antioxidant mechanisms in cancer cells

The injectable activates the systemic pathway

The upregulation of GPx2 triggers the activity of the Wnt pathway and enhances the dismutation of hydrogen peroxide, the inhibition of apoptosis, and the alleviation of oxidative stress

Besides, overactivation of ACSL4 and LOXs can also convert PUFAs into lipid peroxide

But being established does not automatically mean being the best fit for everyone

Interestingly, an emerging body of evidence suggests that micro RNAs (miRNAs, small non-coding RNAs involved in the post-transcriptional regulation of gene expression) could be putative biomarkers for detecting neurodegeneration Thus, recent reviews have shown that some miRNAs are differentially associated with AD by modulating the expression of important genes involved in A production (e.g., BACE1 ) or inflammation (Goodall et al., 2013