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Clinical cohorts reveal that approximately 40% of AUD patients meet the criteria for MDD during active addiction, with 1520% continuing to exhibit treatment-resistant depressive symptoms after achieving sobriety, suggesting ethanol-induced neurotoxicity may cause irreversible alterations in mood-regulating circuits (McHugh and McBride 2020

The research does show potential in improving brain healthbut experts wouldnt go so far to call it neuroprotective

13 These techniques narrow the drug discovery process and improve understanding of drug candidate interactions with biological systems, aiding the development of effective therapeutics

Hsu, WH, LaBella, KA, Lin, Y, Xu, P, Lee, R, Hsieh, CE, Yang, L, Zhou, A, Blecher, JM, Wu, C, Lin, K, Shang, X, Jiang, S, Spring, DJ, Xia, Y, Chen, P, Shen, JY, Kopetz, S , DePinho, RA