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B-class plexins regulate several small GTPases, interacting with Rac [21], Rnd1-2-3 [22], R-Ras [23], M-Ras [24] and RhoD [25] and regulating Rho via PDZRhoGEF/LARG [26] and p190RhoGAP [27]

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doi: 10.1097/RLI.0b013e3181e943d2

[DOI] [PubMed] [Google Scholar] 19.Kleszczyski K., Bilska B., Stegemann A., Flis D.J., Ziolkowski W., Pyza E., Luger T.A., Reiter R.J., Bhm M., Slominski A.T

As an essential subunit of the NADPH oxidase complex, NCF1 is required for neutrophil ROS generation, and its genetic variations are linked to increased susceptibility to autoimmune disorders including rheumatoid arthritis and lupus (91)