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People with pernicious anemia, may benefit from sublingual B12 as they lack intrinsic factor and have a lot of trouble absorbing B12 through their digestive system (Ankar, 2020)

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People who cannot absorb vitamin B 12 should continue to eat a well-balanced diet that provides other nutrients (folic acid, iron, and vitamin C) necessary to produce healthy blood cells

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Despite extensive biochemical knowledge of cobalamin metabolism and its physiological importance, the optimal supplementation route for maintaining or restoring adequate vitamin B12 levels remains debated