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Metabolic flux analysis using 13 C glucose 13 C-labeled glucose (U- 13 C6, 99%) was obtained from Cambridge Isotope Laboratories

Parasympathetic function is assessed by measuring the variability of the R-R interval of hearts beat by different maneuvers (normal breathing, Valsalva, stand up)

92,93 EVs are small lipid double-layer membrane vesicles containing a variety of biological contents such as RNA, proteins, and lipids, which convey vital signals among cells and mediate intercellular communications

The concentration of the drug (C P ) after 6 hrs = Loading dose (C 1 ) + Concentration by infusion (C 2 ) N.B: To determine the concentration of the drug in the body after infusion has been stopped, first the final concentration of drug at the end of the infusion is to be calculated and considered as 0

After being taken up by the liver from the bloodstream, melatonin undergoes enzymatic conversion to produce 6-hydroxymelatonin sulfate, which is then excreted in the urine [28]

KDM6A is known to have tumor-suppressive activity [103]