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Recent studies have shown that elimination of senescent cells can restore proper homeostasis to aging tissue

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Aging is shaped by twelve hallmarks of aging - interconnected processes that drive cellular and systemic decline

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The expression of the VD metabolism genes CYP2R1 and CYP27A1 (25-hydroxylase), CYP27B1 (1--hydroxylase), and vitamin D receptor (VDR) were downregulated in the livers of mice fed an HFD (GSH- deficient) compared with control diet-fed group
