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Description
2016;8:a022061
Stem Cells 34 (3), 653667
Hockel, M
Afatinib, the first covalent inhibitor of EGFR approved by the FDA, binds to Cys797 residue on the kinase domain of EGFR in the DFG-in conformation (94)
doi:10.1016/0166-2236(79)90071-7
This is paralleled by altered NMDA receptor function, where Pb acts as a noncompetitive antagonist, modifying subunit-specific receptor sensitivity and interfering with binding at sites typically regulated by zinc
