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The downstream effects of NNMT inhibition by 5-amino-1MQ create a cascade of beneficial metabolic changes at the cellular level

Currently, this combination is the only approved chemotherapy for use against mesothelioma
Feigin VL, Roth GA, Naghavi M et al (2016) Global burden of stroke and risk factors in 188 countries, during 19902013: a systematic analysis for the Global Burden of Disease Study 2013

Because AOD-9604 does not bind to growth hormone receptors in liver, muscle, or adipose tissue, it cannot trigger the metabolic pathways that mediate growth hormones counter-regulatory effects on glucose metabolism
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Tumour necrosis factor-alpha in human adipose tissue -- from signalling mechanisms to clinical implications

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