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ROS are a major factor of skin aging, involving damage to DNA, the inflammatory response, reduced production of antioxidants, and the generation of matrix metalloproteinases (MMPs) that degrade collagen and elastin in the dermal skin layer, leading to skin wrinkles and reduced elasticity (103)

Wang Z, Zhang Y, Ju E, Liu Z, Cao F, Chen Z, et al

The degradation of lysine to glutarate We next considered the source of GA, a compound that has not yet been shown to play an important and widespread role in metabolism

We also summarized the findings of the studies on the drugs or inhibitors targeting ferroptosis and further discussed their feasibility as potential therapies for treating hemorrhagic stroke

doi: 10.1016/S0735-6757(98)90129-2

PLoS One 10 , e0116396 (2015)