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Autonomic nervous system dysfunction (ANSD) is a relevant contributor to some of the clinical features in RTT patients that leads to multiple impairments ranging from anxiety, GI dysfunction, breathing disturbances, peripheral vascular control alteration (19) to sleep issues (3), heart rate variability (HRV) (2022), and increased risk of sudden death (23, 24)

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Informacin importante * Suplemento alimenticio

To minimize costs, a minimal general mitochondrial medicine regimen may include a multivitamin, a B50 vitamin (as opposed to a B100 compound that is often too large for many individuals to safely swallow), one or more antioxidant(s), and coenzyme Q10, with additional agents selected based on the individual patients genotype and phenotype (Table 1)

L-Carnitine in liquid form: easier to consume and dispense than tablets or capsules

The best option depends on formulation, dosage, and added ingredients like ALA or vitamins