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These strategies may include antioxidant supplementation, pharmacological agents with antioxidant properties (e.g., statins), and strict inflammation control

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Glutathione is the bodys primary endogenous antioxidant present in every cell and responsible for neutralizing free radicals, supporting liver detoxification, and protecting cellular integrity

Although ROS play essential roles in the maintenance of basal cellular activities such as chondrocyte proliferation and matrix remodeling in cartilage, excessive oxidative stress causes detrimental events such as cellular senescence 36,121 , dedifferentiation 122 , and apoptosis 123