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Specifically, the most relevant SNPs affecting DAO enzyme functionality in Caucasian individuals are rs10156191, rs1049742, rs2268999 and especially rs1049793 [69,71]

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Both reaction rates and protein abundances (inputs) were varied using Latin hypercube sampling (LHS), and partial rank correlation coefficients (PRCCs) 36 were calculated and significant PRCCs reported for pAkt and pERK (outputs) at 120 min that represents steady state (Fig