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Gene-based treatments signify an additional frontier, present the potential to directly modulate disease-associated pathways in conditions such as asthma and cystic fibrosis (Robbins et al

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Transamination Reactions: Glutamate can also be converted to -KG through transamination with aspartate by the action of aminotransferases, which transfers the amino group to oxaloacetate, producing -KG

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Because increased concentrations of dopamine lead to the diffusion of dopamine throughout a greater area of CNS tissue, the area and number of cells exposed to dopamine is directly proportional to the amount of dopamine released

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