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This section provides a detailed analysis of these critical determinants, synthesizing current evidence to elucidate their individual and synergistic roles in initiating, amplifying, and perpetuating the transition from acute nociception to persistent chronic pain

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FertSteril 2021] 2) 5-alpha reductase inhibitors (5ARIs) These medications are used to shrink the size of enlarged prostates over time and include finasteride (Proscar), dutasteride (Avodart)

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Genome Med (2014) 6(12):540

Although aberrant BDNF/TrkB signaling is implicated in several neurological, neurodegenerative and psychiatric disorders, neurotrophin-based therapy is challenging and is limited by improper pharmacokinetic properties of BDNF