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Intranasal delivery bypasses first-pass degradation and adds a partial direct nose-to-brain route through olfactory and trigeminal pathways

[DOI] [PubMed] [Google Scholar] 114.Liu T., Zhang L., Joo D., Sun S.C

The disruption of white matter integrity and connectivity in regions such as the cingulate gyrus, accessory cingulate gyrus, and amygdala in OSA patients was reported when used DTI to construct brain structural network data, these abnormalities might be the basis for the reduced efficiency of inter-regional communication and cognitive information processing [20]
