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The role of interleukin-8 in cancer cells and microenvironment interaction

Biomolecules 10 , 40 (2019)

Multiple pharmacological inhibitors, including S-p-bromobenzyl-glutathione cyclopentyl diester (BBGC), ethyl pyruvate, TER 117 and curcumin, have been shown to sensitize cancers to chemotherapy [121, 244, 245]

Researchers are also working to optimize delivery methods, with a special emphasis on improving intranasal formulations and determining the best dosing schedules through dose-response studies [6]

Currently, CRISPR is limited to in vitro and animal studies due to safety and ethical barriers, but advances in delivery vectors and base editing technologies may accelerate clinical translation (Inoue et al., 2023

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