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10.1371/journal.pone.0184709 37 KooltheatN.Pankla SranujitR.ChumarkP.PotupP.Laytragoon-LewinN.UsuwanthimK

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On other hand, arsenic-based compounds, with arsenic trioxide as the prototype, have already been approved by the FDA as a gold standard differentiation therapy to acute promyelocytic leukemia (APL) that is refractory to conventional therapies [133]

This review covers the role of mitochondrial metabolism, not only in providing metabolites for proliferation but also in dictating function of adaptive immune responses, with extensive focus on T cell activation, expansion, effector functions, and memory formation

Knockdown of VMAT2 in mice disturbs DA vesicle storage and leads to mild and progressive DA neurodegeneration, accompanied by elevated levels of cysteinyl-DAQs adducts, suggesting enhanced DA oxidation and DAQ toxicity [45]