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Other strategies developed have involved LPS-targeted antibodies (the monoclonal antibody HA.1A, or recombinant human activated protein C) or blocking LPSTLR4 pathways, however, with unsuccessful results [79]

Consequently, there is an increase in intestinal permeability and translocation of intestinal flora, leading to the release of enterogenic endotoxins into the bloodstream which act on the original organ via the circulatory system, further exacerbating deterioration of the intestinal organ

[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Wang C.-K., Yang S.-C., Hsu S.-C., Chang F.-P., Lin Y.-T., Chen S.-F., Cheng C.-L., Hsiao M., Lu F.L., Lu J

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Formally notifying the ISSM and the DAA Rep/SCO when changes occur that might affect accreditation/certification