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The resulting damage intensifies cellular dysfunction and suppresses mitochondrial respiration, thereby aggravating the bioenergetic failure that underlies severe sepsis (Vctor et al., 2009

Most established and accessible

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Philadelphia: Saunders/Elsevier

Also, consider the Law of Diminishing Returns

[DOI] [PMC free article] [PubMed] [Google Scholar] Tsvetanova NG, Irannejad R, von Zastrow M