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By contrast, the intranuclear amount of p65 of NF-B, which can suppress the gene expression of CYP1A2, CYP2E1, and CYP3A11, was higher in untreated IL-1ra KO than WT mice

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To think about why that is, lets first consider an analogy

The extension of lifespan requires the oxidative stress response regulators SKN-1, SEK-1, and HLH-30