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However, in genotype 1a replicons, the C316Y substitution has low replication capacity that must be compensated for by additional "compensatory" substitutions, including L392F or M414T, resulting in an increase in replication levels of at least 10-fold [19]

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Unlike conventional hormones encoded in nuclear DNA, this peptide is transcribed from the mitochondrial genome and then released into the cytosol and nucleus under stress conditions
