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Sci Rep 15(1):22416 Funding This research was funded by the Key R&D Program of Shandong Province (2025LZGC033), Liaocheng Municipal Bureau of Science and Technology, High-talented Foreign Expert Introduction Program (GDWZ202401), the National Key R&D Program of China (grant number 2023YFD1302004)

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Figure 4 shows the intricate amino acid metabolic network, and the identified enzymatic changes in amino acid metabolism

Ethics Approval All animal experiments were performed according to protocols approved by the Institutional Animal Care and Use Committee of Dalian Municipal Central Hospital

Data and code availability All data reported in this paper will be shared by the lead contact upon request

Additionally, Yang et al