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Anxiety has emerged as a reported side effect in some patients taking semaglutide, affecting approximately 5-8% of users in real-world data
doi: 10.1038/s41386-019-0384-x

This was the partners second try for FDA approval after the regulator rejected Ngenlas first bid in January 2022

however, direct data linking GLP-1 signaling to improved healthspanthrough measures such as physical function, frailty indices, cognition, or time-to-disabilityremain limited in humans

The slowed gastric emptying may also reduce oral intake, as patients feel fuller longer and may struggle to consume adequate fluids
