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A dysregulated and functionally impaired microbiome tend to promote chronic low-grade inflammation, immune dysregulation, oxidative stress, DNA damage and metabolic rewiring, contributing to the carcinogenic effects of hr-HPV integrating oncogenes into the host genome

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Vitamin D receptors (DVR) in the brain are found primarily in dopaminergic neurons in the SNpc (Eyles et al., 2005) and VDR mRNA expression in the blood is a useful risk marker for identifying PD patients (Scherzer et al., 2007)

However, in hypertensive patients, endothelial function is often compromised, leading to what is known as endothelial dysfunction. Typically, these cells modulate blood vessel dilation and contraction by releasing factors like NO, prostaglandins, and endothelin, thereby stabilizing blood pressure

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