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However, if APAP overdose overwhelms the aforementioned detoxification pathways and depletes GSH to less than 30% of its normal level in the liver, NAPQI accumulates and forms covalent bonds with sulfhydryl groups on cysteine and lysine residues in the mitochondria of the hepatocytes [23,27]

it must be administered by a qualified healthcare professional

doi: 10.3390/MOLECULES27092903 13 BlombergBGreve-Isdahl MohnKBrokstadKAZhouFLinchausenDWHansenBAet al

Is increased tissue ferritin a risk factor for atherosclerosis and ischaemic heart disease

This is not a formal ceiling because no FDA-approved limit exists, but it represents the upper range of what is supported by preclinical scaling and provider experience

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