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The nodes were annotated as metabolites based on the accurate mass (within 5 ppm), isotope pattern, retention time, and diagnostic product ions

In these types of cells, folate deficiency reduces de novo thymidylate biosynthesis, leading to uracil mis-incorporation during DNA repair and synthesis, which causes DNA strand breaks and ultimately leads to malignant transformation [158,167,183]

Similarly, in cisplatin-induced renal injury, microRNA (miR)-4835p (37) promotes the expression of GPX3, thereby mitigating oxidative stress and exerting a protective effect on renal injury (38)

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Furthermore, various disease-related signaling pathways also play a role in regulating the process of iron oxidation

In addition to PCD, a variety of diseases and conditions have been found to be associated with secondary CoQ 10 deficiency (SCD), which refers to all the conditions in which the etiology of the CoQ 10 deficiency is not a molecular lesion in the CoQ 10 biosynthetic pathway