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The BM connects cells, supports intercellular communication, and interacts with the extracellular matrix to control the BBB permeability[27]

death of a loved one, over-exercise, overwork, medication intolerance, excessive exogenous steroid overload from medications, infectious processes such as snake/spider bites or pneumonia) can overwhelm the already decompensated and constitutionally weak adrenals, leading to a rapid descent into Phase D (bypassing earlier phases) within days or weeks