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Pharmacol.,2011, 43(1), 612 27

Zunzunegui MV

Common Acne Types: Comedonal acne : Whiteheads and blackheads Inflammatory acne : Papules, pustules, and nodules Cystic acne : Deep, painful, and prone to scarring Hormonal acne : Often along the jawline, flares around menstrual cycles Conventional Treatment: Why It Often Fails Dermatology often treats acne with: Topicals : Benzoyl peroxide, salicylic acid, retinoids Antibiotics : Doxycycline, minocycline Hormonal agents : Birth control, spironolactone Isotretinoin (Accutane) : For severe cystic acne These can be helpful but often come with downsides: Temporary relief Rebound breakouts Side effects : Gut issues, liver stress, mood swings No investigation of root cause Functional medicine asks a different question: Why is your body producing acne in the first place

Intestinal fatty acid oxidation is now recognized to be substantially regulated by the PR-domain-containing 16 (PRDM16) proteins, which are essential for the survival and proliferation of transit-amplifying progenitor cells 22

C-Met expression is controlled by the -catenin signaling and downregulated by inhibition of Wnt signaling using Frzb and DNLRP5, two Wnt antagonists [103, 104]

Mechanisms by which ROS cause cerebral tissue damage are not well understood but ROS are reported to trigger a variety of molecular cascades that increase blood-brain barrier permeability and alter brain morphology, thus causing neuroinflammation, and neuronal death (Gu et al., 2011)