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Laboratory studies demonstrate that FOXO4-DRI can eliminate chemotherapy-induced senescent cells that may contribute to administration resistance, while the timing of senolytic administration relative to chemotherapy requires careful optimization in experimental designs

It also impacts cellular signalling in brain tissue, with potential applications in targeting neurodegenerative diseases and alleviating brain fog

These combinations should be approached with caution, as the interactions between multiple TrkB-modulating compounds have not been systematically studied in clinical settings

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No approval, physicians can't recommend them