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Additionally, the study utilizing the destabilization of the medial meniscus (DMM) model demonstrates that n-3 PUFA-derived 17-hydroxy docosahexaenoic acid (17-HDHA) is linked to reduced pain during loading, confirming the murine DMM models utility in investigating the 17-HDHA pathway as a potential therapeutic targeting for alleviating OA pain (152)

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Nat Cell Biol (2008) 10(5):6118

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In addition to inhibiting NF-kB signaling, riboflavin can also inhibit critical components of the non-canonical inflammasomes, such as caspase-1 activity 47 , either via the AIM2 cytosolic innate immune receptor, which recognizes double-stranded DNA (dsDNA) released during cellular perturbation, or via the Nod-like receptor NLRC4, which recognizes bacterial ligands such as flagellin and the type three secretion system (T3SS) 47

National Natural Science Foundation of China (82360861), Natural Science Foundation of Jiangxi Province (20232BAB206173), Science and Technology Research Project of Jiangxi Provincial Department of Education (GJJ2201430), The Talent Starting Fund Project of Gannan Medical University (Grant number QD202012), The Talent Starting Fund Project of Gannan Medical University (Grant number QD202208), and Open Project of the Key Laboratory of the Ministry of Education for the Prevention of Cardiovascular and Cerebrovascular Diseases, Gannan Medical University (XN202015)