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Studies have shown that circulating ghrelin and GHS-R expression in tissues are altered under the conditions of high-fat diet-feeding, obesity and aging 9, 12

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Memantine improves ''off periods'' in patients with advanced Parkinson's disease

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91 It has been shown to activate the Nrf2 pathway, enhancing the expression of detoxification enzymes and efflux transporters

FIGURE 1 In the first set of experiments, animals were separated into one of the following groups ( n = 6 per group): Control (0.9% saline followed by 0.9% saline), C/Control (caffeine followed by 0.9% saline), C/L-theanine (caffeine followed by L-theanine), C/Mg-T1 [caffeine followed by Magnesium-L-theanine (8% Mg 2+ )], or C/Mg-T2 [caffeine followed by Magnesium-L-theanine (18% Mg 2+ )]