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10.4049/jimmunol.2200475 14 HuZ.ZhaoM.ShenH.WeiL.SunJ.GaoX.et al (2026)

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Glutathione, a potent antioxidant, is naturally present in both plants and animals

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Furthermore, a high-fat diet increases free fatty acids, which inhibit TLR-activated hexokinase activity and interfere with the tricarboxylic acid cycle, thereby enhancing the production of mitochondrial reactive oxygen species (mtROS), increasing the unfolded protein response, altering cellular transcription, and increasing IL-23, ultimately exacerbating the inflammatory symptoms of psoriatic skin (Mogilenko et al., 2019)

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