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A 2014 United Nations Office on Drugs and Crime report found that between 2006 and 2010 in the United States, there was a 59 percent increase in marijuana-related emergency room visits and a 14 percent increase in cannabis-related hospital admissions

It binds within the ERR ligand-binding domain and enhances transcriptional activity at ERR response elements, recruiting coactivators such as PGC-1/

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